Characterization of iodothyronine deiodinase cDNAs in the chipmunk (Tamias asiaticus).
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چکیده
منابع مشابه
Naturally acquired rabies in an eastern chipmunk (Tamias striatus).
Rabies in an Eastern chipmunk was detected by fluorescent-antibody testing and mouse inoculation. The results were independently confirmed, and the virus was recovered from tissue culture.
متن کاملCloning and Characterization of Type III Iodothyronine Deiodinase from the Fish Oreochromis niloticus.
Type III iodothyronine deiodinase (D3) catalyzes the inner ring deiodination (IRD) of T4 and T3 to the inactive metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2), respectively. Here we describe the cloning and characterization of complementary DNA (cDNA) coding for D3 in fish (Oreochromis niloticus, tilapia). This cDNA contains 1478 nucleotides and codes for a protein of 267 amino acids, inclu...
متن کاملInhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site.
We report that aurone derivatives of plant extracts produce potent, dose-dependent, and ultimately complete inhibition of three different metabolic monodeiodination pathways catalyzed by rat liver microsomal type I iodothyronine deiodinase. These data show that (3'),4',4,6-(tetra)trihydroxyaurones are the most potent naturally occurring plant-derived inhibitors of this deiodinase enzyme (IC50 V...
متن کاملSeasonal changes in thermoregulatory responses to hypoxia in the Eastern chipmunk (Tamias striatus).
Mammalian heterotherms are known to be more tolerant of low oxygen levels than homeotherms. However, heterotherms demonstrate extreme seasonality in daily heterothermy and torpor expression. Because hypoxia depresses body temperature (T(b)) and metabolism in mammals, it was of interest to see if seasonal comparisons of normothermic animals of a species capable of hibernation produce changes in ...
متن کاملIsolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase.
The type 3 iodothyronine deiodinase (D3) is a selenoenzyme that inactivates thyroid hormones by removing a iodine from the 5-position of the tyrosyl ring. D3 is highly expressed in many tissues during the early stages of development, and its activity is regulated by selected growth factors and various hormones. To gain further insights into the structure, functional role, and regulation of this...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34663-3